Enhancing oral bioavailability of poorly soluble drugs with mesoporous silica based systems: opportunities and challenges
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چکیده
منابع مشابه
Pharmaceutical Technologies for Enhancing Oral Bioavailability of Poorly Soluble Drugs
The oral bioavailability of BCS (biopharmaceutics classification system) class II drugs with poor solubility and reasonable permeability is limited by the drug dissolution step from drug products. Though prodrug approach is an exciting way of improving the oral bioavailability, it requires extensive studies to establish the safety profile of prodrugs in humans. In view of the increasing market ...
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Oral administration is the most convenient route among various routes of drug delivery as it offers high patient compliance. However, the poor aqueous solubility and poor enzymatic/metabolic stability of drugs are major limitations in successful oral drug delivery. There are several approaches to improve problems related to hydrophobic drugs. Among various approaches, nanotechnology based drug ...
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Submit Manuscript | http://medcraveonline.com J Anal Pharm Res 2015, 1(1): 00001 in terms of dissolution but the non-traditional formulation approaches can lead to a significant increase in dissolution and solubility particularly required for drugs applied in medium to higher dosages [3]. Such dosages’ requirements go along with the necessity to evaluate other formulation technologies for enhan...
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ژورنال
عنوان ژورنال: Drug Development and Industrial Pharmacy
سال: 2018
ISSN: 0363-9045,1520-5762
DOI: 10.1080/03639045.2018.1542709